Error Threshold Quasispecies

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BACKGROUND: Influenza viruses exist as a large group of closely related viral genomes, also called quasispecies. required a frequency of 0.5% or higher. This threshold exceeds the background error rate resulting from the RT-PCR.

A viral quasispecies is a group of viruses related by a similar mutation or mutations, competing within a highly mutagenic environment. The theory predicts that a.

May 17, 2014. The asymptotic behavior of the quasispecies model is determined by the equilibrium p. Error thresholds for molecular quasispecies as phase.

ring the loss of quasispecies localization. This means that the rate of evolution can increase without error catastrophe. B. Error threshold for quasispecies with.

But it was soon recognized that quasispecies theory made a useful tool for the study of viral evolution. Its most fundamental prediction is the existence of an error threshold. If the mutation rate exceeds this threshold, then all.

In phase 2 trials, telaprevir, a hepatitis C virus (HCV) genotype 1 protease inhibitor, in combination with peginterferon–ribavirin, as compared with peginterferon.

The error threshold is also controlled by the fitness landscape. they will form a quasispecies and will be able to support longer sequence lengths than a fit.

Keywords: Cancer; RNA viruses; Quasispecies; Genomic instability; Genetic instability; Tumor progression; Phase transitions; Error threshold. 1. Introduction.

We study the presence of Eigen's error threshold and mutational. shaped distribution in phenotypic space (quasispecies), centered around the master.

Read "Error threshold in RNA quasispecies models with complementation, Journal of Theoretical Biology" on DeepDyve, the largest online rental service for scholarly.

Error threshold in RNA quasispecies models with complementation Josep Sardany´es1,2, ∗ and Santiago F. Elena1,3 1Instituto de Biolog´ıa Molecular y Celular de.

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The error threshold. The quasispecies model suggests the existence of an error threshold for selective competence. According to Eq. ,

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Background The interferon-free combination of the protease inhibitor ABT-450 with ritonavir (ABT-450/r) and the NS5A inhibitor ombitasvir (also known as ABT-267) plus.

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Error threshold in RNA quasispecies models with complementation. we show the prediction of the error threshold for a simple quasispecies model without.

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